南京农业大学动物医学院导师：茅翔

姓名	茅翔	性别	男
出生日期	1972年8月	籍贯	安徽肥东
毕业院校
研究方向:	病毒与宿主细胞相互作用动物疫病病原分子结构与功能的关系
个人简历:	博士，教授，博士生导师。 1993 年毕业于安徽大学化学系化学专业，获学士学位；1996年毕业于中国科学院上海药物研究所天然产物化学专业，获硕士学位；2001年毕业与中国科学院上海植物生理生态研究所微生物学专业，获博士学位。2002年7月至2009年4月赴美德克萨斯大学休斯顿分校进行博士后研究工作。2009年4月至今在南京农业大学动物医学院传染病组任教，主要从事分子病毒学及分子免疫学的教学和科研工作。
代表性论著:	1. Hassan Z.A. Ishag, Chen Li, Li Huang, Ming-xia Sun, Bo Ni, Chun-xia Guo, Xiang Mao. Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral protein. Virus Research. 2013, 171: 89-96. 2. Hassan Z.A. Ishag, Chen Li, Li Huang, Ming-xia Sun, Fengjuan Wang, Bo Ni, Thowaiba Malik, Pu-yan Chen, Xiang Mao. Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo. Archive of Virology. 2013, 158: 349-358 3. Ming-xia Sun, Li Huang, Rui Wang, Ya-ling Yu, Chen Li, Peng-peng Li, Xiao-chun Hu, Hong-ping Hao, Hassan. A. Ishag, Xiang Mao* Porcine Reproductive and Respiratory syndrome Virus Induce Autophagy to Promote Virus Replication. Autophagy 2012,8: 1434-1447 4. Chen Li, Li-ying Zhang, Peng-peng Li, Ming-Xia Sun, Li Huang, Jian-chao Wei, Yi-lin Yao, Hassan Isahg, Pu-yan Chen, Xiang Mao Inhibition of Japanese Encephalitis Virus Entry into the Cells by the Envelope glycoprotein Domain III (EDIII) and the Loop 3 Peptide Derived From EDIII. Antiviral Research, 2012, 94:179-83 5. Li Huang, Rui-bing Cao, Ning Wang, Ke Liu, Jian-chao Wei, Hassan Isahga, Li-jie Song Wei-yong Zuo, Bin Zhou, Wei-wu Wang, Xiang Mao, Pu-yan Chen The design and Recombinant Protein expression of a Consensus Porcine Interferon: CoPoIFN-α. Cytokine，2012, 57: 37-45 6. Li Huang, Yuan-peng Zhang, Ya-ling Yu, Ming-xia Sun, Chen Li, Bo Ni, Xiu-hua Wang, Pu-yan Chen, Xiang Mao* Role of cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection on MARC-145 cells. Biochemical and Biophysical Research Communications，2011, 414: 545-550 7. Li Huang, Xiang Mao, Najmoutin G. Abdulaev, Tony Ngo, Wei Liu, and Kevin D. Ridge One-step Purification of a Functional, Constitutively Activated Form of Visual Arrestin. Protein expression and purification 2011,82: 55-60 8. Feng X, Liu T, Wang F, Cao R, Zhou B, Zhang Y, Mao X, Chen P, Zhang H. Isolation, antiproliferation on tumor cell and immunomodulatory activity of BSP-I, a novel bursal peptide from chicken humoral immune system. Peptides 2011 32:1103-1109 9. Feng X, Su X, Wang F, Wei J, Wang F, Cao R, Zhou B, Mao X, Zheng Q, Chen P. Isolation and potential immunological characterization of TPSGLVY, a novel bursal septpeptide isolated from the bursa of Fabricius Peptides. 2010, 31:1562-1568 10. Wei JC, Huang YZ, Zhong DK, Kang L, Ishag H, Mao X, Cao RB, Zhou B, Chen PY. Design and evaluation of a multi-epitope peptide against Japanese encephalitis virus infection in BALB/c mice Biochem Biophys Res Commun. 2010;396(4):787-92. 11. Zhou B, Liu K, Wei JC, Mao X, Chen PY. Inhibition of replication of classical swine fever virus in a stable cell line by the viral capsid and Staphylococcus aureus nuclease fusion protein. J Virol Methods. 2010 Jul;167(1):79-83 12. Najmoutin G. Abdulaev, Xiang Mao, Eva Ramon, Tony Ngo, Justyna Mysliwy, John P. Marino Kevin D. Ridge Detecting Long Range structural coupling in a heterotrimeric G protein alpha-subunit by NMR Spectroscopy Photochemistry and Photobiology 2009, 85(2):431-6. 13. Eva Ramon, Xiang Mao, Kevin D. Ridge Studies on the stability of the human cone visual pigments Photochemistry and Photobiology 2009, 85(2):509-16 14. Zhiyong Ren, Xiang Mao, Claudia Mertens, Ravi Krishnaraj, Jie Qin, Pijus K. Mandal, Michael J. Romanowski, John S. McMurray，Xiaomin Chen Crystal structure of unphosphorylated STAT3 core fragment Biochemical and Biophysical Research Communications 2008, 374:1-5 15. Yaomin Hu, Yan Ren, Robert Z. Luo, Xiang Mao, Xiujun Li, Xu Cao, Lu Guan, Xiang Chen, Jianwei Li,Yang Long, Xiangxun Zhang, Haoming Tian Novel mutations of the lipoprotein lipase gene associated with hypertriglyceridemia in members of type 2 diabetic pedigrees J. Lipid Res. 2007, 48:1681-1688 16. Xiang Mao, Zhiyong Ren, Gregory N. Parker, Holger Sondermann, Michael A. Pastorello, Wei Wang, John S. McMurray, Borries Demeler, James E. Darnell, and Xiaomin Chen. Structural Bases of Unphosphorylated STAT1 Association and Receptor Binding. Molecular Cell. 2005, 17: 761-771 17. Minghao Zhong, Melissa A. Henriksen, Kenji Takeuchi, Olaf Schaefer, Bin Liu, Johanna ten Hoeve, Zhiyong Ren, Xiang Mao, Xiaomin Chen, Ke Shuai, and James E. Darnell, Jr. Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proceedings of National Academy of Science of the United States of America. 2005;102:3966-71 18. Xiang Mao, Xiaomin Chen. Crystallization of X-ray crystallographic analysis of human STAT1. Acta Crystallographica Section F61. 2005; 666-668 19. Arata Nishimoto, Yinhua Yu, Zhen Lu, Xiang Mao, Zhiyong Ren, Stephanie S. Watowich, Gordon B. Mills, Warren S-L. Liao, Xiaomin Chen, Robert C. Bast Jr., and Robert Z. Luo. A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Cancer Research. 2005, 65:6701-6710 20. Shulin Zhuang, Jianwei Zou, Yongjun Jiang, Xiang Mao, Bing Zhang, Haichun Liu and Qingsen Yu Some Insights into the Stereochemistry of Inhibition of Macrophage Migration Inhibitory Factor with 2-Fluoro-p-hydroxycinnamate and Its Analogues from Molecular Dynamics Simulations. Journal of Medicinal Chemistry, 2005, 48:7208-7214. 21. Xiang Mao, Weiwu Wang, Weihong Jiang, Guoping Zhao His23β and Glu455β of the Pseudomonas sp. 130 glutaryl-7-amino cephalosporanic acid acylase are crucially important for efficient autoproteolysis and enzymatic catalysis. The Protein Journal. 2004, 23:197-204. 22. 马伟, 茅翔, 卢捷, 姜卫红, 覃重军, 赵国屏. 头状链轮丝菌(Streptoverticillum aespitosus) ATCC27422染色体基本复制起始区(oriC)的序列分析与功能研究. 生物化学与生物物理学报. 2003, 35: 930-936. 23. 张怡轩，郭晓奎，茅翔，缪有刚，吴春福，赵国屏. 钩端螺旋体血小板激活因子乙酰水解酶基因特征分析.中国人兽共患病杂志. 2003, 19:12-16 24. 马伟,茅翔,卢捷,姜卫红,焦瑞身,覃重军,赵国屏. 头状链轮丝菌染色体复制起始区的克隆和对变铅青链霉菌的转化. 生物工程学报. 2002, 18: 662-666. 25. 卢捷,马伟,茅翔,覃重军,姜卫红,焦瑞身. 除虫链霉菌复制起始区克隆和功能初步分析. 生物化学与生物物理学报. 2002, 34:712-718. 26. Xi Huang, Rong Zeng, Xiaoming Ding, Xiang Mao, Yi Ding, Zihe Rao, Yong Xie, Weihong Jiang, Guoping Zhao. Affinity alkylation of the Trp-B4 residue of the β-subunit of the glutaryl 7-amino-cephalosporanic acid acylase of Pseudomonas sp. 130. Journal of Biological Chemistry. 2002, 277:10256-10264 27. 茅翔, 张菁, 李勇, 何宇炯, 王恩多, 杨蕴刘, 焦瑞身, 姜卫红, 赵国屏. 假单孢菌 sp.130 GL-7-ACA酰化酶的核苷酸和蛋白质序列分析. 生物工程学报. 2002, 18 : 63-68. 28. 李祥, 张伟, 茅翔, 蔡煊, 杨蕴刘, 赵国屏, 姜卫红. GL-7ACA酰化酶表达检测系统的建立. 生物工程学报. 2001, 17: 673-677. 29. Yong Li, Jianfeng Chen, Weihong Jiang, Xiang Mao, Guoping Zhao, Enduo Wang. In vivo post-translational processing and subunit reconstitution of cephalosporin acylase from Pseudomonas sp. 130. European Journal of Biochemistry. 1999, 262: 713-719. 30. 宋刚，宋后燕，茅翔. 用计算机模型研究葡激酶与人微小纤溶酶原的相互作用. 高技术通讯. 1999, 9:48-51g
联系方式：	地址：南京市卫岗1号南京农业大学动物医学院邮编： 210095 电话： 025-84396335 传真： 025-84396335 E-mail: xmao@njau.edu.cn